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KMID : 0603820150210020077
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Journal of Experimental & Biomedical Science
2015 Volume.21 No. 2 p.77 ~ p.83
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Soybean Peptides Induce Apoptosis in HeLa Cells by Increasing Oxidative Stress
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Sung Ho-Joong
Jeong Yu-Jin
Kim Ji-hyun
Jung Eun-Sun
Jun Jin-Hyun
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Abstract
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Soy proteins have been extensively studied because of its multiple health benefits. However, the effects of soy proteins on human cervical cancer cells are still unclear. Therefore, this study investigated the effects of soy proteins on HeLa cells and human fibroblasts by using soybean peptides (SPs). SPs selectively increased the generation of reactive oxygen species and apoptosis in HeLa cells but not in fibroblasts. In addition, SPs suppressed the migration of HeLa cells. Although the molecular mechanisms underlying the effects of SPs on human cervical cancer cells need to be investigated further, our findings provide insights on the therapeutic effects of soy protein on cervical cancer.
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KEYWORD
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Soybean peptides, Reactive oxygen species, Apoptosis, Migration, HeLa cells
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